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How long does it take for stitches to dissolve : The time it takes for stitches to dissolve can vary depending on the type of stitches used. Generally, absorbable stitches, made from materials like polyglycolic acid or polydioxanone, dissolve within 1 to 2 weeks. Non-absorbable stitches, made from materials like nylon or silk, require removal by a healthcare professional after about 1 to 2 weeks.